PROGUANIL HYDROCHLORIDE
- Product Name
- PROGUANIL HYDROCHLORIDE
- CAS No.
- 537-21-3
- Chemical Name
- PROGUANIL HYDROCHLORIDE
- Synonyms
- M-5943;chlorproguanil;Chloroproguanil;PROGUANIL HYDROCHLORIDE;N1-3,4-Dichlorophenyl-N5-isopropyldiguanide;1-(3,4-Dichlorophenyl)-5-isopropylbiguanide;N-(3,4-Dichlorophenyl)-N'-isopropyldicarbonimido/ic diamide/imido;N-(3,4-Dichlorophenyl)-N'-(1-Methylethyl)iMidodicarboniMidic DiaMide;(1E)-1-[amino-(3,4-dichloroanilino)methylidene]-2-propan-2-ylguanidine;Imidodicarbonimidic diamide, N-(3,4-dichlorophenyl)-N'-(1-methylethyl)-
- CBNumber
- CB2488954
- Molecular Formula
- C11H15Cl2N5
- Formula Weight
- 288.18
- MOL File
- 537-21-3.mol
PROGUANIL HYDROCHLORIDE Property
- Melting point:
- 120-121 °C
- Boiling point:
- 350.7±52.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 10.77±0.10(Predicted)
- color
- White to Off-White
- BCS Class
- 1
- Stability:
- Hygroscopic
N-Bromosuccinimide Price
- Product number
- API0009147
- Product name
- CHLORPROGUANIL
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $750.75
- Updated
- 2021/12/16
- Product number
- API0009147
- Product name
- CHLORPROGUANIL
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $1963.5
- Updated
- 2021/12/16
PROGUANIL HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
PROGUANIL HYDROCHLORIDE is an antimalarial agent used in combination with Dapsone (D193250).
Definition
ChEBI: Chlorproguanil is a dichlorobenzene.
Clinical Use
Malaria chemoprophylaxis
Drug interactions
Potentially hazardous interactions with other drugs
Anticoagulants: effect of warfarin possibly enhanced.
Antimalarials: avoid concomitant use with
artemether/lumefantrine; increased antifolate effect
with pyrimethamine.
Metabolism
Proguanil is metabolised in the liver to the active metabolite, cycloguanil, and to p-chlorophenylbiguanide which is inactive, mainly by cytochrome P450, CYP 2C19 and slightly by CYP 3A4. Unlike proguanil and p-chlorophenylbiguanide, cycloguanil is not concentrated in erythrocytes so concentrations of cycloguanil in plasma and whole blood are similar. About 40-60% of a dose of proguanil is excreted in the urine, 60% of this as the unchanged drug, 30% as cycloguanil, and 8% as p-chlorophenylbiguanide. About 10% of a dose is excreted in the faeces.